Dr Leo Schep was employed by the University of Otago from 1987 to 2019. From 1987 until 2000 he was employed at the School of Pharmacy where he conducted research and was a tutor in various labs and papers. From 2000 to 2019, he was employed at the New Zealand National Poisons Centre. There, his full-time employment consisted of providing poisons information to health professionals and the general public concerning all aspects of acute poisoning. He has lectured on various subjects and continues to lecture on Forensic Toxicology at the University of Otago. Dr Schep is also a member of the Independent Forensic Practitioners Institute.

Additionally, he has provided advice, and presented seminars, to the New Zealand Police, New Zealand Defence Force as well as Emergency Departments and other health care providers. He has also provided teaching seminars throughout the country, to various community organisations, maraes and secondary schools.